A berberine combination beat placebo in 93 adults, with three big caveats

A berberine combination beat placebo in 93 adults

Berberine is sold online as a natural alternative to prescription weight-loss drugs, usually on evidence far thinner than the marketing. A randomised, double-blind, placebo-controlled trial published in Nutrients tested a fixed combination of berberine, white mulberry leaf extract and chromium picolinate in 93 Greek adults with obesity over 12 weeks, and found real differences against … Read more

Orforglipron beat oral semaglutide on blood sugar and weight over 52 weeks

Orforglipron beat oral semaglutide over 52 weeks

Eli Lilly posted the full results of ACHIEVE-3 to ClinicalTrials.gov on 15 September 2026, and they are the first detailed head-to-head numbers between the two oral GLP-1 drugs. Over 52 weeks in 1,698 adults with type 2 diabetes, the higher dose of orforglipron lowered blood sugar further than the higher dose of oral semaglutide and … Read more

Teens on GLP-1 drugs had fewer recorded suicide-related events in an 18,444-patient study

Teens on GLP-1 drugs had fewer recorded suicide-related events in an 18,444-patient study

Adolescents with obesity who started semaglutide, liraglutide or tirzepatide were less likely to have a recorded suicide-related event over up to three years than matched adolescents managed with lifestyle intervention, according to an electronic health records study published on 14 September in Diabetes, Obesity and Metabolism. It points away from psychiatric harm in the age … Read more

Nine people reacted to compounded wellness vials shipped to their homes

Peptide Review Desk safety report: compounded wellness vials recalled over elevated endotoxin

Nine people reported fever, chills, chest pain or vomiting after receiving compounded injections that a Houston pharmacy has now recalled nationwide. Centric Compounding is pulling six lots of glutathione, Myer’s Cocktail and Tri-Immune Boost, injectables sold to support immunity, fatigue and general wellness, after the glutathione raw ingredient used to make them was found to … Read more

An online fat burner was found to contain fluoxetine and DNP

Peptide Review Desk safety report: fat burner recalled over undeclared fluoxetine and DNP

A weight-loss supplement sold directly to consumers online has been recalled nationwide after FDA laboratory testing found two undeclared drugs inside the same box. The daytime tablets of Lipofit Extreme Fat Burner 2.0 contained fluoxetine, a prescription antidepressant. The nighttime tablets contained 2,4-dinitrophenol, a substance the FDA describes as a pesticide, dye, wood preservative and … Read more

A European obesity society says the drugs have outrun the care around them

A European obesity society says the drugs have outrun the care around them

The European Association for the Study of Obesity has published a position statement whose argument is not about whether incretin drugs work. It treats that as settled. The argument is that everything around the prescription has failed to keep pace: patient selection, monitoring, clinician training and access have all moved more slowly than the drugs, … Read more