A new cohort study adds to a now-consistent finding: people taking semaglutide or tirzepatide are diagnosed with non-scarring hair loss more often than matched non-users. This is not a fringe signal — hair loss is printed on the Wegovy label, among the adverse reactions occurring in at least 2% of treated patients and more often … Read more
A Barcelona hospital followed 83 adults with obesity through a year of routine care and measured what most weight-loss studies only estimate: fat, lean tissue, resting energy expenditure and handgrip strength. The 44 patients on semaglutide lost substantially more weight than the 39 on a lifestyle programme alone. They also lost lean tissue — about … Read more
The self-pay price of the 4 mg Wegovy tablet rises from $149 to $199 a month on 1 September 2026. This is not a leak or a forecast: Novo Nordisk published the end date when it launched the offer, and the footnote was still on NovoCare’s own pricing page when we read it on 31 … Read more
The Spanish Menopause Society published an expert position statement on 25 August covering the use of GLP-1 and dual incretin medications in peri- and postmenopausal women with overweight or obesity. It sets out 20 positions across body composition, cardiometabolic risk, musculoskeletal health, monitoring and interaction with hormone therapy. The most useful thing in it, for … Read more
A systematic review and meta-analysis published on 29 August pooled nine randomised trials covering 6,239 adults with overweight or obesity but without diabetes, and found that injected semaglutide reduced a standard marker of inflammation by roughly 40% alongside the weight loss it is prescribed for. Serious adverse events were no more common than on placebo. … Read more
A large propensity-matched cohort study published in Diabetes, Obesity and Metabolism on 27 August 2026 found that people who started a GLP-1 receptor agonist were modestly more likely to be diagnosed with diabetic retinopathy, and more likely to undergo a retinopathy procedure, than matched people who started a DPP-4 inhibitor instead. The same study found … Read more
Trial results describe what happens under close supervision with motivated volunteers. A study published in August in The Lancet Diabetes & Endocrinology asked a harder question: among 45,093 real patients with obesity and type 2 diabetes, how many actually hit a meaningful combined target a year after starting treatment? The answer for semaglutide was 3.0%. … Read more
The standard maintenance dose of Wegovy is 2.4 mg a week. STEP UP, a phase 3b randomised trial published in The Lancet Diabetes & Endocrinology, tested three times that — 7.2 mg — against both the standard dose and placebo over 72 weeks. Average weight loss was 20.7% on the high dose, 17.5% on 2.4 … Read more